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Filtered Search Results
Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000669983 CINACALCET IMPURITY 10MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000669987 PALBOCICLIB IMPURITY 5MG
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Medchemexpress LLC Alverine citrate | 5560-59-8 | 99.49% | 1 G
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Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM. It is a drug used for functional gastrointestinal disorders, acting directly on the muscle in the gut to cause relaxation. In-vitro binding studies indicate that Alverine citrate has a high affinity for 5-HT1A receptors and a weak affinity for 5-HT3 and 5-HT4 subtypes. Alverine may increase Ca influx during action potentials by inhibiting the inactivation of L-type Ca channels, and may also suppress evoked activity by inhibiting the sensitivity of contractile proteins to Ca2+.
- 5-HT1A receptor antagonist
- Used for functional gastrointestinal disorders
- Acts directly on gut muscle, causing relaxation
- High affinity for 5-HT1A receptors
- Weak affinity for 5-HT3 and 5-HT4 subtypes
- Available as a solid and in solution (in DMSO)
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000669967 CANAGLIFLOZIN IMPURI 1MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000670016 CANAGLIFLOZIN IMPURI 1MG
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Apexbio Technology LLC Bromhexine HCl 611-75-6 10g
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Bromhexine Hydrochloride is an expectorant compound utilized frequently in respiratory research to examine mucolytic mechanisms It functions primarily by disrupting acidic polysaccharide fibers within bronchial mucus reducing mucus viscosity and facilitating mucociliary clearance The compound is routinely employed in in vitro studies involving respiratory epithelial cells and ex vivo respiratory tract tissues to investigate its pharmacological influence on mucus production and secretion Reported IC50 values for Bromhexine Hydrochloride in mucolytic assays typically range between 30-50 M under standard experimental conditions Its applications extend to the study of respiratory disorders associated with abnormal mucus secretion enabling researchers to better characterize molecular pathways involved in mucus regulation and investigate potential therapeutic targets
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000567982 R788-DISODIUM-HEXAH2O
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Medchemexpress LLC Bromfenac sodium | 91714-93-1 | 99.9% | 100 MG
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Bromfenac sodium is a potent and orally active inhibitor of COX enzymes, specifically targeting COX-1 and COX-2. It is primarily utilized in ocular inflammation research due to its significant anti-inflammatory properties.
- Potent and orally active COX inhibitor with low IC50s
- Inhibits transforming growth factor-β2-induced epithelial-mesenchymal transition
- Suppresses transforming growth factor-β2-induced cell migration
- Demonstrates significant anti-inflammatory activity in various animal models
- More potent than indomethacin in blocking erythema
- Reduces paw volume in animal studies
- Blocks abdominal constriction to ACh challenge
- Partially reduces corneal staining in specific keratoconjunctivitis sicca models
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Selleck Chemical LLC Maraviroc 10mM/1mL 376348-65-1 UK-427857
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Maraviroc (UK-427857) is a CCR5 antagonist for MIP-1?, MIP-1? and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000695047 TICAGRELOR IMPURITY 50MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000695048 RIVAROXABAN IMPURITY 1G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000695666 TICAGRELOR IMPURITY 100MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000695676 APIXABAN IMPURITY 13 10G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000695823 TICAGRELOR IMPURITY 25MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000696348 ROSUVASTATIN SODIUM 50MG
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